Progranulin rat

NA.32

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Lyophilized from 0.2 μm-filtered solution in PBS.

Reconstitute with 100 μL deionized water.

Signal peptide and rat progranulin (aa 1-602) are fused at the C-terminus to a FLAG^®-tag.

FLAG is a registered trademark of sigma-aldrich Co. LLC

rat

expressed in HEK 293 cells

FLAG^® tagged

>95% (SDS-PAGE)

lyophilized

~65 kDa by SDS-PAGE

pkg of 10 μg

sigma-aldrich

avoid repeated freeze/thaw cycles

<0.1 EU/μg endotoxin, tested

white

P23785

wet ice

−20℃

rat ... Grn(29143)

12 - Non Combustible Liquids

WGK 2