Rabbit anti-cAbl Antibody, Affinity Purified

NA.41

The epitope recognized by PLA0204 maps to a region between residue 850 and 900 of human v-abl Abelson murine leukemia viral oncogene homolog 1 using the numbering given in entry NP_005148.2 (GeneID 25).

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

c-Abl is the human cellular homolog of a the v-Abl viral oncogene. v-Abl was originally discovered as a mouse cell-derived sequence in the genome of the Abelson murine leukemia virus (A-MuLV), a transforming retrovirus isolated by the laboratory of Dr. H.T. Abelson. c-Abl is a tyrosine kinase from the Src-family of tyrosine kinases that localizes to both the cytoplasm and nucleus. It bears an SH2 (src-homology 2) and SH3 (src-homology 3) domain responsible for mediating c-Abl protein-protein interactions. c-Abl is implicated to play a role in multiple cellular processes such as cell cycle checkpoint signaling, apoptosis, cell differentiation, cell adhesion, and transcriptional regulation. Chromosomal translocations involving the c-Abl gene are associated with human leukemias.

rabbit

100

affinity purified immunoglobulin

primary antibodies

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human

immunofluorescence: 1:500- 1:2,000
immunohistochemistry: 1:500- 1:2,000
immunoprecipitation (IP): 2- 5 μg/mg

NP_005148.2

wet ice

2-8℃

rabbit ... cAbl(25)

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12 - Non Combustible Liquids

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