Rabbit anti-CDC20 Antibody, Affinity Purified

NA.41

The epitope recognized by PLA0173 maps to a region between residue 449 and 499 of human cell division cycle 20 using the numbering given in entry NP_001246.2 (GeneID 991).

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

CDC20 is a WD repeat containing cell cycle-regulator that binds to and activates the ubiquitin-ligase activity of the APC/c (anaphase-promoting complex/cyclosome). APC/c ubiquitinating activity is responsible for the degradation of securin and cyclin B that prompts the onset of anaphase and exit from mitosis. CDC20 has also been reported to form a complex with histone deacetylases and can function as a transcriptional repressor involved in cell cycle arrest. As a regulator of APC/c activity, CDC20 plays a key role in the spindle-assembly checkpoint.

rabbit

100

affinity purified immunoglobulin

primary antibodies

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human, mouse

immunohistochemistry: 1:500- 1:2,000
immunoprecipitation (IP): 2-10 μg/mg
western blot: 1:2,000- 1:10,000

NP_001246.2

Q12834

wet ice

2-8℃

rabbit ... CDC20(991)

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