Rabbit anti-CRM1 Antibody, Affinity Purified

NA.41

The epitope recognized by PLA0109 maps to a region between residue 1025 and the C-terminus (residue 1071) of human Chromosome Region Maintenance 1 (Exportin 1) using the numbering given in entry NP_003391.1 (GeneID 7514).

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Chromosome region maintenance 1 protein homolog (CRM1) is the Ran-GTP-binding nuclear export receptor for proteins bearing a leucine rich nuclear export signal and RNAs. CRM1 also possesses a mitotic function as it localizes to kinetochores, and with Ran-GTP, recruits Ran-GTPase-activating protein (Ran-GAP1) and Ran-binding protein (Ran-BP2) for proper mitotic spindle assembly and chromosome segregation. Additionally, CRM1 is suggested to function as a loading dock of various cell cycle and checkpoint factors such as cyclins, Cdks, p53 and BRCA1, to regulate proper chromosome duplication and genomic stability.

rabbit

100

affinity purified immunoglobulin

primary antibodies

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human, mouse

immunohistochemistry: 1:1,000-1:5,000
immunoprecipitation (IP): 2-10 μg/mg
western blot: 1:2,000-1:10,000

NP_003391.1

wet ice

2-8℃

rabbit ... CRM1(7514)

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