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SB-204070 hydrochloride
产品别名
148702-58-3
SB-204070 hydrochloride
(1-Butyl-4-piperidinyl)methyl-8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H27ClN2O4 · HCl |
| Molecular weight | 419.34 |
| MDL number | MFCD03453014 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278704 |
| NACRES | NA.77 |
| Application【应用】 | SB-204070 hydrochloride was used to study the role of 5-HT metabolites in trypsin-induced anion secretion in mouse cecum. |
| Biochem/physiol Actions【生化/生理作用】 | SB-204070 is a highly potent and specific antagonist of 4-HT4 receptor. It inhibits cholinergic and noncholinergic transmission and blocks the contractions of proximal colon in guinea pigs and relaxation of human colon circular smooth muscle. Selective 5-HT4 serotonin receptor antagonist. |
| Legal Information【法律信息】 | Manufactured and sold under exclusive license from GlaxoSmithKline Pharmaceuticals |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | solid |
| mp | 243-245 ℃ (lit.) |
| solubility【溶解性】 | H2O: 20 mg/mL (with heating) |
| SMILES string | Cl[H].CCCCN1CCC(CC1)COC(=O)c2cc(Cl)c(N)c3OCCOc23 |
| InChI | 1S/C19H27ClN2O4.ClH/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18;/h11,13H,2-10,12,21H2,1H3;1H |
| InChI key | YEQGKAOSYSXEPU-UHFFFAOYSA-N |
| Gene Information | human ... HTR4(3360) |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
