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SB-3CT
| 产品编号： | 3217007 |
| 规格： | ≥98% (HPLC), powder |
| CAS NO： | 292605-14-2 |
| 包装规格： | 5 MG，25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3217007 | 5 MG | 3310 | |||
| 3217007 | 25 MG | 13280 |
产品别名
292605-14-2
SB-3CT
2-[[(4-phenoxyphenyl)sulfonyl]methyl]-Thiirane
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H14O3S2 |
| Molecular weight | 306.40 |
| MDL number | MFCD09836266 |
| PubChem Substance ID【PubChem化学物质编号】 | 329824474 |
| NACRES | NA.77 |
| Application【应用】 | SB−3CT has been used as irreversible inhibitor of matrix metallopeptidase 9 (MMP9) in cell cultures to exclude reciprocal regulation. |
| Biochem/physiol Actions【生化/生理作用】 | SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor. Matrix metalloproteinases (MMPs) are involved in a number of activities including angiogenesis and embryogenesis. In particular, gelatinases A (MMP-2) and B (MMP-9), are thought to facilitate tumor metastasis. SB-3CT exhibits a covalent mechanism based behavior in inhibition of MMP-2 and MMP-9. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. SB-3CT has been shown to directly bind to the zinc in the catalytic site of MMP-2. SB-3CT does not affect the activities of MMP-1 (Ki = 206 μM) MMP-3 (Ki = 15 μM), or MMP-7 (Ki = 96 μM). |
| Legal Information【法律信息】 | Sold under license of U.S. Patent 6,703,415. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | DMSO: >20 mg/mL |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | O=S(=O)(CC1CS1)c2ccc(Oc3ccccc3)cc2 |
| InChI | 1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2 |
| InChI key | LSONWRHLFZYHIN-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
