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SB265610

产品编号:3217015
规格:≥98% (HPLC)
CAS NO:211096-49-0
包装规格:5 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
32170155 MG1650
321701525 MG7560
产品别名

211096-49-0

SB265610

SB 265610

N-(2-Bromophenyl)-N′-(7-cyano-1H-benzotriazol-4-yl)urea

1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C14H9BrN6O
Molecular weight
357.16
MDL number
MFCD09971124
PubChem Substance ID【PubChem化学物质编号】
329825416
NACRES
NA.77
Application【应用】
SB265610 has been used:
  • as a cysteine-amino acid-cysteine (CXC)-chemokine receptor type 2 (CXCR2) antagonist to study its effects on the binding of chemokine with G-protein coupled receptors (GPCR)
  • as a CX-chemokine receptor type 1 (CXCR1) inhibitor to study its effect on the chemotactic activity of chemokines on inflammatory cells
  • as a CXCR2 antagonist to study its effect on migration of neutrophils to the rat brain

Biochem/physiol Actions【生化/生理作用】
SB265610 is a potent and selective CXCR2 chemokine receptor antagonist. It has a Kd = 2.5 nM.
Features and Benefits【特点和优势】
This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
color【颜色】
white to light brown
solubility【溶解性】
DMSO: 15 mg/mL, clear
storage temp.【储存温度】
2-8℃
SMILES string
Brc1ccccc1NC(=O)Nc2ccc(C#N)c3nn[nH]c23
InChI
1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21)
InChI key
SEDUMQWZEOMXSO-UHFFFAOYSA-N
packaging【包装】
5, 25 mg in glass bottle
安全信息
Pictograms【象形图】
GHS07
Signal word【警示用语:】
Warning
Hazard Statements
H302
Hazard Classifications【危险分类】
Acute Tox. 4 Oral
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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