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SCH-28080
| 产品编号： | 3217108 |
| 规格： | ≥98% (HPLC), solid |
| CAS NO： | 76081-98-6 |
| 包装规格： | 10 MG，50 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
76081-98-6
SCH-28080
2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H15N3O |
| Molecular weight | 277.32 |
| MDL number | MFCD00834620 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278810 |
| NACRES | NA.77 |
| Application【应用】 | SCH-28080 was used to treat zebrafish embryos to study the role of H+/K+-ATPase in establishment of left-right axis during development. |
| Biochem/physiol Actions【生化/生理作用】 | SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase. The novel antiulcer agents, SCH-28080 and SCH-32651 were examined for their ability to inhibit the H+K+ ATPase enzyme activity in a preparation of microsomal membranes from rabbit fundic mucosa. SCH- 28080 inhibited the isolated enzyme activity with a potency similar to omeprazole, IC50s of 2.5 and 4.0 μM respectively. SCH 32651 was less potent exhibiting an IC50 of 200.0 μM. Both compounds may therefore exert their antisecretory activity via a direct inhibition of the parietal cell H+K+ ATPase. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | white to light tan |
| solubility【溶解性】 | DMSO: soluble >10 mg/mL H2O: insoluble |
| compatibility【相容性】 | for use with ABI 7700 |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | Cc1nc2c(OCc3ccccc3)cccn2c1CC#N |
| InChI | 1S/C17H15N3O/c1-13-15(9-10-18)20-11-5-8-16(17(20)19-13)21-12-14-6-3-2-4-7-14/h2-8,11H,9,12H2,1H3 |
| InChI key | PYKJFEPAUKAXNN-UHFFFAOYSA-N |
| packaging【包装】 | 10, 50 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
