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SGC707
产品别名
SGC707
1-Isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-yl-ethyl)-urea
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H18N4O2 |
| Molecular weight | 298.34 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825739 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | SGC707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). SGC707 has an IC50 value of 50 nM and >100-fold selectivity over other methyltransferases and non-epigenetic targets. SGC707 binds to PRMT3 with KD of 50 nM (ITC), and inhibits histone methylation in cells with an IC50 value below 1 μM. For full characterization details, please visit the SGC707 probe summary on the Structural Genomics Consortium (SGC) website. XY1 is the negative control for the active probe, SGC707. To request a sample of the negative control from the SGC, click here. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc |
| Features and Benefits【特点和优势】 | SGC707 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC. This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
| Other Notes【其他说明】 | SGC707 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the SGC707 probe summary on the Chemical Probes Portal website. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to light brown |
| solubility【溶解性】 | DMSO: 20 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=NC=C3C=C2 |
| InChI | 1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22) |
| InChI key | DMIDPTCQPIJYFE-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS05 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H318 |
| Precautionary Statements | P280 - P305 + P351 + P338 + P310 |
| Hazard Classifications【危险分类】 | Eye Dam. 1 |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
