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SIB 1757
产品别名
SIB 1757
6-Methyl-2-(phenylazo)-3-pyridinol
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C12H11N3O |
| Molecular weight | 213.24 |
| MDL number | MFCD00506102 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278717 |
| NACRES | NA.77 |
| Application【应用】 | SIB 1757 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies. |
| Biochem/physiol Actions【生化/生理作用】 | SIB 1757 is a highly selective mGluR5 metabotropic glutamate receptor antagonist. It non-competitively inhibits glutamate-induced increase in Ca2+ at human metabotropic glutamate receptor 1 (hmGluR1).1 Inhibition of mGlu5 receptor renders protection to neurons2 against methamphetamine-induced oxidative damage.3 |
| Features and Benefits【特点和优势】 | This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥99% (HPLC) |
| form【形式】 | crystalline |
| color【颜色】 | red |
| SMILES string | Cc1ccc(O)c(\N=N\c2ccccc2)n1 |
| InChI | 1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3/b15-14+ |
| InChI key | LOCPVWIREQIGNQ-CCEZHUSRSA-N |
| Gene Information | human ... GRM1(2911), GRM5(2915) |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 - H335 |
| Precautionary Statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
