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SKA-31
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3240264 | 5 MG | 1770 | |||
| 3240264 | 25 MG | 9030 |
产品别名
40172-65-4
SKA-31
Naphtho[1,2-d]thiazol-2-ylamine
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C11H8N2S |
| Molecular weight | 200.26 |
| MDL number | MFCD00051329 |
| PubChem Substance ID【PubChem化学物质编号】 | 329824457 |
| Biochem/physiol Actions【生化/生理作用】 | SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure. SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice, suggesting potassium channel activation as a therapeutic target for hypertension. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| solubility【溶解性】 | DMSO: ≥30 mg/mL |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | Nc1nc2c(ccc3ccccc23)s1 |
| InChI | 1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13) |
| InChI key | FECQXVPRUCCUIL-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 - H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Eye Irrit. 2 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
