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SKI II
| 产品编号： | 3240281 |
| 规格： | ≥98% (HPLC), solid |
| CAS NO： | 312636-16-1 |
| 包装规格： | 10 MG，50 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3240281 | 10 MG | 2160 | |||
| 3240281 | 50 MG | 7520 |
产品别名
312636-16-1
SKI II
4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H11ClN2OS |
| Molecular weight | 302.78 |
| MDL number | MFCD00733553 |
| PubChem Substance ID【PubChem化学物质编号】 | 24724614 |
| NACRES | NA.77 |
| Application【应用】 | SKI II has been used to study the regulatory mechanism and signaling pathway induced by SKI II in inhibiting tumor growth. Human cisplatin-resistant gastric cancer cell line was treated with SKI-II to study the mechanism of reversion of multidrug resistance.1 |
| Biochem/physiol Actions【生化/生理作用】 | Sphingosine kinase (SK) plays a pivotal role in regulating tumor growth and SK can act as an oncogene. Expression of SK RNA is significantly elevated in a variety of solid tumors, compared with normal tissue from the same patient. A number of novel inhibitors of human SK were identified, and several representative compounds were characterized in detail. These compounds demonstrated activity at sub- to micromolar concentrations, making them more potent than any other reported SK inhibitor, and were selective toward SK compared with a panel of human lipid and protein kinases. Kinetic studies revealed that the compounds were not competitive inhibitors of the ATP-binding site of SK. 4-[4-(4-chloro-phenyl)-thiazol-2-ylamino]-phenol (SKI-II) inhibitor is orally bioavailable, detected in the blood for at least 8 h, and showed a significant inhibition of tumor growth in mice with IC50 = 0.5 μM; SKI II does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCa at concentrations up to 60 μM.SKI II induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9-4.6 μM). |
| Features and Benefits【特点和优势】 | This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
| Other Notes【其他说明】 | Product is air and light sensitive |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| storage condition【储存条件】 | protect from light |
| color【颜色】 | off-white |
| solubility【溶解性】 | DMSO: ≥20 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Oc1ccc(Nc2nc(cs2)-c3ccc(Cl)cc3)cc1 |
| InChI | 1S/C15H11ClN2OS/c16-11-3-1-10(2-4-11)14-9-20-15(18-14)17-12-5-7-13(19)8-6-12/h1-9,19H,(H,17,18) |
| InChI key | ZFGXZJKLOFCECI-UHFFFAOYSA-N |
| packaging【包装】 | 10, 50 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
