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SL327
| 产品编号： | 3240293 |
| 规格： | ≥98% (HPLC), Mixture of E & Z isomers, solid |
| CAS NO： | 305350-87-2 |
| 包装规格： | 5 MG，25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3240293 | 5 MG | 2240 | |||
| 3240293 | 25 MG | 5650 |
产品别名
305350-87-2
SL327
SL-327
α-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile
SL 327
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H12F3N3S |
| Molecular weight | 335.35 |
| MDL number | MFCD06411432 |
| PubChem Substance ID【PubChem化学物质编号】 | 329824537 |
| NACRES | NA.77 |
| Application【应用】 | SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats. It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus. SL327 has been used as an inhibitor of dual specificity mitogen-activated protein kinase (MEK) in Zebrafish embryos and lymphatic endothelial cell (LEC). |
| Biochem/physiol Actions【生化/生理作用】 | SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| storage condition【储存条件】 | desiccated protect from light |
| color【颜色】 | white to off-white |
| mp | 127-128.2 ℃ |
| solubility【溶解性】 | DMSO: >10 mg/mL H2O: insoluble |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F |
| InChI | 1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+ |
| InChI key | JLOXTZFYJNCPIS-FYWRMAATSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
