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Sorbinil
产品别名
68367-52-2
Sorbinil
CP 45634
(+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione
(4S)-6-Fluoro-2,3-dihydro-spiro[4H-1-benzopyran-4,4′-imidazolidine]-2′,5′-dione
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C11H9FN2O3 |
| Molecular weight | 236.20 |
| MDL number | MFCD00867380 |
| PubChem Substance ID【PubChem化学物质编号】 | 329824587 |
| NACRES | NA.77 |
| Application【应用】 | Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group. Sorbinil may be used in cell signaling and neuroscience studies. |
| Biochem/physiol Actions【生化/生理作用】 | Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy. Sorbinil is an inhibitor of Aldose Reductase (AR). AR family members AKR1B1 and AKR1B10 have additionally been shown to play roles in inflammation and cancer. |
| Features and Benefits【特点和优势】 | This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| optical activity【旋光性】 | [α]/D +50 to +60°, c = 1 in methanol |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | DMSO: ≥20 mg/mL |
| originator【创始人】 | Pfizer |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1 |
| InChI | 1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1 |
| InChI key | LXANPKRCLVQAOG-NSHDSACASA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
