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Splitomicin
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3242712 | 5 MG | 1180 |
产品别名
5690-03-9
Splitomicin
1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C13H10O2 |
| Molecular weight | 198.22 |
| MDL number | MFCD08705254 |
| PubChem Substance ID【PubChem化学物质编号】 | 24724608 |
| NACRES | NA.77 |
| Application【应用】 | Splitomicin was used to inhibit SIRT1 in human aortic endothelial cells and sirtuins in human breast cancer cells. Mouse leukaemic monocyte macrophage cell line was treated with Splitomicin prior to cholesterol efflux studies. |
| Biochem/physiol Actions【生化/生理作用】 | Splitomicin, a derivative of β-naphthol is an inhibitor of Silent Information Regulator 2 (SIR2). It inhibits the NAD+-dependent deacetylase activity of Sir2 in vitro. It increases the levels of cyclic AMP by inhibiting the activity of cyclic AMP phosphodiesterase, interferes with mobilization of intracellular Ca+2 and ATP release. This results in inhibition of platelet aggregation that is effective in cardiovascular and cerebrovascular diseases. Sir2p (silent information regulator) and HDAC inhibitor. |
| Features and Benefits【特点和优势】 | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C1CCc2c(O1)ccc3ccccc23 |
| InChI | 1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2 |
| InChI key | ISFPDBUKMJDAJH-UHFFFAOYSA-N |
| packaging【包装】 | 5 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
