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Terrein
产品别名
582-46-7
Terrein
(+)Terrein
Terrain
基本信息
| Empirical Formula【经验(实验)分子式】 | C8H10O3 |
| Molecular weight | 154.16 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Terrein is a bioactive fungal metabolite that has plant growth inhibition and antibacterial activities. Terrein reduces melanin levels in a dose-dependent manner as well as tyrosinase protein production. In mammals, there are three melanocyte-specific enzymes: tyrosinase, tyrosinase-related protein-1 (TRP-1), and TRP-2 that are involved in tyrosine conversion into melanin (melanogenesis). Terrein inhibits melanin synthesis by reducing tyrosinase production via extracellular signal-regulated protein kinase (ERK) activation. ERK activation is followed by microphthalmia-associated transcription factor (MITF) down regulation, which is required for tyrosinase expression. |
| Preparation Note【制备说明】 | Terrein is soluble in water at 1-1.10 mg/ml and yields a clear, colorless solution. It is also soluble in DMSO. Hence, the product may be reconstituted in water or DMSO. |
产品性质
| biological source【生物来源】 | Aspergillus terreus |
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥98% (HPLC) |
| storage condition【储存条件】 | protect from light |
| solubility【溶解性】 | H2O: soluble 1-1.10 mg/mL, clear, colorless DMSO: soluble |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C8H10O3/c1-2-3-5-4-6(9)8(11)7(5)10/h2-4,7-8,10-11H,1H3/b3-2+ |
| InChI key | MHOOPNKRBMHHEC-NSCUHMNNSA-N |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
