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西梅脱寡肽酶 来源于地衣芽孢杆菌
Thimet Oligopeptidase from Bacillus licheniformis
产品别名
西梅脱寡肽酶 来源于地衣芽孢杆菌
Thimet Oligopeptidase from Bacillus licheniformis
基本信息
| Enzyme Commission (EC) Number【酶学委员会(EC)编号】 | 3.4.24.15 ( BRENDA | IUBMB ) |
| NACRES | NA.54 |
| General description【一般描述】 | Thimet oligopeptidase is considered essential in the degradation of collagen in collaboration with collagenolytic enzymes. Thimet oligopeptidase (TOP) is a neuropeptidase involved in the hydrolysis of gonadotropin-releasing hormone, a key component of the hypothalamic-pituitary-gonadal axis. |
| Application【应用】 | Thimet oligopeptidase can be used for the degradation of collagen in combination with collagenases. It can also be used for the hydrolysis of neuropeptides such as bradykin, neurotensin, and amyliod-β-peptide. Thimet oligopeptidase has been used in a study to investigate the effect of acute cocaine administration in male rats on TOP specific activity and mRNA levels in prosencephalic brain areas related with the reward circuitry: ventral striatum, hippocampus, and frontal cortex. |
| Preparation Note【制备说明】 | This enzyme has been affinity chromatographically purified using a niquel affinity column. It contains a 6-Histidine tag in its C-terminus. A working solution of this enzyme can be prepared in 20 mM phosphate buffered saline solution, pH 7.0, or sterile and deionized water, pH 7.0. |
产品性质
| Quality Level【质量水平】 | 200 |
| recombinant【重组】 | expressed in E. coli |
| form【形式】 | powder |
| mol wt【分子量】 | ~77 kDa |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H332 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Inhalation - Skin Irrit. 2 |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
