TPO mouse

NA.32

TPO (thrombopoietin) is a hematopoietic cytokine expressed in multiple tissue types. It is predominantly produced by liver and kidney and acts as a ligand for the cell surface receptor c-mpl.

TPO (thrombopoietin) is the key regulator of thrombopoiesis for platelet lineage. In both mice and humans, inactivation of this gene results in significant decrease in number of mature platelets produced by marrow progenitors. Transgenic mice with increased expression of this protein show progressive fibrosis and osteosclerosis of the bone marrow, as well as histological changes in kidneys, leading to mesangioproliferative glomerulopathy.

Lyophilized from 10 mM Tris, pH 8.0.

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

mouse

expressed in E. coli

≥98% (HPLC)
≥98% (SDS-PAGE)

lyophilized

≥1.0 ng/mL ED₅₀

18.7 kDa

pkg of 10 μg

<0.1 EU/μg endotoxin, tested

white

P40226

wet ice

−20℃

mouse ... Thpo(21832)

GHS07

Warning

H315 - H319 - H335

P261 - P305 + P351 + P338

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

12 - Non Combustible Liquids

WGK 3