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甲氧苄啶 乳酸盐
Trimethoprim lactate salt
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3255332 | 250 MG | 4690 |
产品别名
23256-42-0
甲氧苄啶 乳酸盐
Trimethoprim lactate salt
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine lactate salt
2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶 乳酸盐
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H18N4O3 · C3H6O3 |
| Molecular weight | 380.40 |
| EC number【EC 号】 | 245-533-1 |
| MDL number | MFCD00171722 |
| PubChem Substance ID【PubChem化学物质编号】 | 329826610 |
| NACRES | NA.85 |
| General description【一般描述】 | Chemical structure: pyrimidine |
| Application【应用】 | Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used clinically to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections. Trimethoprim lactate salt is used as a selection agent. |
| Biochem/physiol Actions【生化/生理作用】 | The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to prokaryote-specific dihydrofolate reductase (DHFR) and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis. |
| Other Notes【其他说明】 | Keep container tightly closed in a dry and well-ventilated place. |
产品性质
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥98% |
| form【形式】 | powder |
| storage condition【储存条件】 | (Keep container tightly closed in a dry and well-ventilated place.) |
| color【颜色】 | white |
| solubility【溶解性】 | H2O: soluble 20 mg/mL |
| Mode of action【作用机制】 | DNA synthesis | interferes enzyme | inhibits |
| antibiotic activity spectrum【抗生素抗菌谱】 | Gram-negative bacteria Gram-positive bacteria mycobacteria |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC(O)C(O)=O.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC |
| InChI | 1S/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6) |
| InChI key | IIZVTUWSIKTFKO-UHFFFAOYSA-N |
| packaging【包装】 | 250 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS06,GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H301 - H361d |
| Precautionary Statements | P202 - P264 - P270 - P280 - P301 + P310 - P405 |
| Hazard Classifications【危险分类】 | Acute Tox. 3 Oral - Repr. 2 |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
