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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3257616 | 25 MG | 2310 |
产品别名
2826-26-8
Tyrphostin 1
(4-Methoxybenzylidene)malononitrile
结构式
基本信息
| Linear Formula【线性分子式】 | CH3OC6H4CH=C(CN)2 |
| Molecular weight | 184.19 |
| MDL number | MFCD00019787 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278751 |
| NACRES | NA.77 |
| Application【应用】 | Tyrphostin 1 has been used to study its effect on the increase of transgene expression in HeLa and NIH3T3 cells. |
| Biochem/physiol Actions【生化/生理作用】 | Tyrphostin 1 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain. Tyrphostin 1 is also known to block EGF-dependent receptor autophosphorylation,. Furthermore, studies have reported that tyrphostin 1 can block Ca2+ channels and inhibit growth in vascular smooth muscle cells,. EGFR tyrosine kinase inhibitor. |
| Features and Benefits【特点和优势】 | This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
| Preparation Note【制备说明】 | Tyrphostin 1 dissolves in chloroform at 50 mg/ml to yield a clear, light yellow solution. It is also soluble in DMSO. |
产品性质
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥98% |
| form【形式】 | solid |
| potency【效能】 | >1250 μM IC50 (negative control) |
| mp | 113-116 ℃ (lit.) |
| solubility【溶解性】 | chloroform: soluble 50 mg/mL, clear, light yellow DMSO: soluble |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | COc1ccc(cc1)\C=C(/C#N)C#N |
| InChI | 1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3 |
| InChI key | UOHFCPXBKJPCAD-UHFFFAOYSA-N |
| Gene Information | human ... EGFR(1956) |
| packaging【包装】 | 25 mg in poly bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
