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Tyrphostin AG 879
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3257629 | 5 MG | 1650 |
产品别名
148741-30-4
Tyrphostin AG 879
α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H24N2OS |
| Molecular weight | 316.46 |
| MDL number | MFCD00236450 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278728 |
| NACRES | NA.77 |
| Application【应用】 | Tyrphostin AG 879 (AG879) has been used for studying its effect on ErbB2 receptor phosphorylation in A431 cells. This study reported that AG879 at 10 muM can cause 15% inhibition of receptor phosphorylation1. AG879 has also been used as a neurotrophic tyrosine kinase receptor inhibitor to study the disruption of Sertoli cell aggregation2. |
| Biochem/physiol Actions【生化/生理作用】 | Tyrphostin AG 879 is known to block RAF-1 and Her-2 expression and exhibit anticancer functions in breast cancer cells3. Furthermore, AG879 is known to block ETK1-PAK1 interactions and the growth of RAS-induced sarcomas in nude mice4. Inhibits the tyrosine kinase activity of the nerve growth factor receptor (TrkA; pp140trk) and heregulin receptor erbB-2 (HER-2). |
| Features and Benefits【特点和优势】 | This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
| Preparation Note【制备说明】 | Tyrphostin AG 879 is soluble in DMSO at 26/ml and is insoluble in water. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | 99% (HPLC) |
| solubility【溶解性】 | DMSO: soluble (at 26 mg/ml) H2O: insoluble |
| SMILES string | CC(C)(C)c1cc(\C=C(/C#N)C(N)=S)cc(c1O)C(C)(C)C |
| InChI | 1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+ |
| InChI key | XRZYELWZLNAXGE-KPKJPENVSA-N |
| Gene Information | human ... ERBB2(2064), NTRK1(4914) |
| packaging【包装】 | 5 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
