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VU0240551
产品别名
893990-34-6
VU0240551
VU0240551-2-D4
N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]-acetamide
CID 7211972
VU0240551-1
SID 56405457
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H14N4OS2 |
| Molecular weight | 342.44 |
| MDL number | MFCD05957363 |
| PubChem Substance ID【PubChem化学物质编号】 | 329829046 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | VU0240551 is a potent, selective KCC2 inhibitor. KCC2 is a potassium-chloride exchanger expressed specifically in neurons. KCC2 functions to lower intracellular chloride concentrations below the electrochemical potential of the cells, thereby increasing the hyperexcitability of the neurons. KCC2 activity enhances GABA and other inhibitory neurotransmission and is implicated in pain processing. VU0240551 was discovered in a high-throughput screen, followed by directed medicinal chemistry. VU0240551 is selective for KCC2 over NKCC1. VU0240551 binds competitively to the K+ site and binds noncompetitively to the Cl- site. VU0240551 is the only small molecule with specificity for a KCC family member. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| solubility【溶解性】 | DMSO: >20 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cc1csc(NC(=O)CSc2ccc(nn2)-c3ccccc3)n1 |
| InChI | 1S/C16H14N4OS2/c1-11-9-23-16(17-11)18-14(21)10-22-15-8-7-13(19-20-15)12-5-3-2-4-6-12/h2-9H,10H2,1H3,(H,17,18,21) |
| InChI key | WJRWSLORVIHRNX-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
