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VU0357017 monohydrochloride

产品编号:3259232
规格:≥98% (HPLC)
CAS NO:1135242-13-5
包装规格:5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
32592325 MG1730
产品别名

1135242-13-5

VU0357017 monohydrochloride

CID 25010775

ML071 hydrochloride

4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride

SID 56353039

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C18H27N3O3 · HCl
Molecular weight
369.89
MDL number
MFCD17215959
PubChem Substance ID【PubChem化学物质编号】
329829053
NACRES
NA.77
Biochem/physiol Actions【生化/生理作用】
VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by scopolamine in a preclinical rodent model.
Features and Benefits【特点和优势】
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
color【颜色】
white to off-white
solubility【溶解性】
DMSO: ≥10 mg/mL
storage temp.【储存温度】
2-8℃
SMILES string
Cl.CCOC(=O)N1CCC(CC1)NCCNC(=O)c2ccccc2C
InChI
1S/C18H27N3O3.ClH/c1-3-24-18(23)21-12-8-15(9-13-21)19-10-11-20-17(22)16-7-5-4-6-14(16)2;/h4-7,15,19H,3,8-13H2,1-2H3,(H,20,22);1H
InChI key
XKJQVUIXSBOCPP-UHFFFAOYSA-N
packaging【包装】
5, 25 mg in glass bottle
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 2
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