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VU0453379 hydrochloride
产品别名
1638646-27-1
VU0453379 hydrochloride
(S)2-CyclopentylN((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro1Hpyrrido[3,4b]indole-4-carboxamide hydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H34N4O2 · HCl |
| Molecular weight | 471.03 |
| MDL number | MFCD28987471 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825812 |
| Biochem/physiol Actions【生化/生理作用】 | VU0453379 is a highly selective CNS penetrant positive allosteric modulator of Glucagon-like peptide-1 (GLP-1) with GLP-1 EC50 = 1.3 μ,M, 59.2% GLP-1 max. VU0453379 potentiated low-dose exenatide to augment insulin secretion in primary mouse pancreatic islets. In a model of Parkinson′s disease it showed a significant reversal of haloperidol-induced catalepsy at 30 mg/kg. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to beige |
| solubility【溶解性】 | H2O: 20 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CN1C2=C(C(C(NC[C@@H]3CCCN3C(C)C)=O)=CN(C4CCCC4)C2=O)C5=CC=CC=C51.Cl |
| InChI | 1S/C26H34N4O2.ClH/c1-17(2)29-14-8-11-19(29)15-27-25(31)21-16-30(18-9-4-5-10-18)26(32)24-23(21)20-12-6-7-13-22(20)28(24)3;/h6-7,12-13,16-19H,4-5,8-11,14-15H2,1-3H3,(H,27,31);1H/t19-;/m0./s1 |
| InChI key | OCMGNMGYQPPMFF-FYZYNONXSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
