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WWL229
产品别名
1338575-28-2
WWL229
4-Nitrophenyl 2-(3-methoxypropyl)piperidine-1-carboxylate
2-(3-Methoxypropyl)-1-piperidinecarboxylic acid 4-nitrophenyl ester
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H22N2O5 |
| Molecular weight | 322.36 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825704 |
| Biochem/physiol Actions【生化/生理作用】 | WWL229 is a highly selective inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3), serine hydrolases involved in lipolysis in addition to their activities as liver detoxification enzymes. WWL229 inhibits mCes3 with an IC50 of 10 μM, but not Ces1f, ABHD6 or other tested serine hydrolases. In a recent study, hCES1 activity was found to be increased two-fold in obese individuals and patients with type 2 diabetes compared to lean subjects, and is thought to generate surplus fatty acids that can deposit ectopically in tissues. WWL229 inhibits adipocyte basal lipolysis and promotes differentiation and lipid storage in adipocytes. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | oil |
| color【颜色】 | colorless to light yellow |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(OC1=CC=C([N+]([O-])=O)C=C1)N2C(CCCOC)CCCC2 |
| InChI | 1S/C16H22N2O5/c1-22-12-4-6-13-5-2-3-11-17(13)16(19)23-15-9-7-14(8-10-15)18(20)21/h7-10,13H,2-6,11-12H2,1H3 |
| InChI key | XVBRVSAGMWRVCK-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
