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XAP044
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3260365 | 25 MG | 5640 |
产品别名
196928-50-4
XAP044
XAP 044
7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H9IO4 |
| Molecular weight | 380.13 |
| MDL number | MFCD00525548 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825781 |
| Biochem/physiol Actions【生化/生理作用】 | XAP044 is a brain penetrant, potent and selective mGlu7 (metabotropic glutamate receptor subtype 7) antagonist that inhibits lateral amygdala long-term potentiation (LTP) in brain slices from wild type mice. XAP044 binds to a pocket localized in mGlu7′s extracellular Venus flytrap domain (VFTD) close to the binding site of the orthosteric agonist L-glutamate. XAP044 exhibits a wide-spectrum anti-stress, antidepressant- and anxiolytic-like efficacy in rodent behavioral model. |
| Other Notes【其他说明】 | Light sensitive. This compound has Iodine and should be kept in the dark. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | protect from light |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 20 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C1C(OC2=CC=C(I)C=C2)=COC3=C1C=CC(O)=C3 |
| InChI | 1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H |
| InChI key | XXZKJJYWINSUMJ-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
