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YIL-781 hydrochloride
产品别名
875258-85-8
YIL-781 hydrochloride
6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone hydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C24H28FN3O2 · xHCl |
| Molecular weight | 409.50 (free base basis) |
| MDL number | MFCD19690924 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825682 |
| Application【应用】 | YIL-781 has been used as a ghrelin receptor (GHSR) antagonist in combination with methanandamide (mAEA) to study its effect on gastric vagal afferent mechanosensitivity. |
| Biochem/physiol Actions【生化/生理作用】 | YIL-781 is a potent antagonist (Ki = 17 nM) of the growth hormone secretagogue receptor (GHS-R1). YIL-781 blocks ghrelin-induced reduction of insulin secretion in rat islets. In vivo, the compound YIL-781 improves glucose tolerance and reduces weight gain. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | , white to yellow to light brown |
| solubility【溶解性】 | H2O: 2 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | room temp |
| SMILES string | CC(C)N(CCC1)C[C@H]1CN(C(C)=N2)C(C3=C2C=CC(OC4=CC=C(F)C=C4)=C3)=O.Cl |
| InChI | 1S/C24H28FN3O2.ClH/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20;/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3;1H/t18-;/m0./s1 |
| InChI key | QQGRMONBDBMLSP-FERBBOLQSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
