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2-((3-三氟甲基)苯基)组胺二马来酸酯
2-((3-Trifluoromethyl)phenyl)histamine dimaleate
产品别名
162049-83-4
2-((3-三氟甲基)苯基)组胺二马来酸酯
2-((3-Trifluoromethyl)phenyl)histamine dimaleate
Compound 39
(2-[2-(3-Trifluoromethyl)phenyl)-1H-imidazol-4-yl]ethanamine dimaleate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H20F3N3O8 |
| Molecular weight | 487.38 |
| MDL number | MFCD08277024 |
| PubChem Substance ID【PubChem化学物质编号】 | 329826803 |
| NACRES | NA.77 |
| Application【应用】 | 2-((3-Trifluoromethyl)phenyl)histamine dimaleate has been used to study the induction of goblet cell secretion in rats3. 2-((3-Trifluoromethyl)phenyl)histamine dimaleate has also been used to study the role of H1 receptor in COX-2 regulation and prostanoid homeostasis in human vascular endothelial cells4. |
| Biochem/physiol Actions【生化/生理作用】 | 2-((3-Trifluoromethyl)phenyl)histamine dimaleate was found to be the most potent and selective H1 histamine receptor agonist of a panel of compounds in functional in vitro studies on histamine H2, H3, and other neurotransmitter receptors. It showed better potency at the guinea pig H1 histamine receptor than at the human H1 histamine receptor (pKi : 5.9). The selectivity of 2-((3-Trifluoromethyl)phenyl)histamine dimaleate was found to be 2138 (H1:H2), > 64 (H1:H3), 1000 (H1:M3), 105 (H1: a1), 708 (H1:β1), and 71 (H1:5HT2A). 2-((3-Trifluoromethyl)phenyl)histamine dimaleate does not cross the blood-brain barrier. |
| Features and Benefits【特点和优势】 | This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
| Preparation Note【制备说明】 | 2-((3-Trifluoromethyl)phenyl)histamine dimaleate is soluble in water at approximately 20 mg/ml. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | off-white |
| solubility【溶解性】 | H2O: ~20 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.NCCc1c[nH]c(n1)-c2cccc(c2)C(F)(F)F |
| InChI | 1S/C12H12F3N3.2C4H4O4/c13-12(14,15)9-3-1-2-8(6-9)11-17-7-10(18-11)4-5-16;2*5-3(6)1-2-4(7)8/h1-3,6-7H,4-5,16H2,(H,17,18);2*1-2H,(H,5,6)(H,7,8)/b;2*2-1- |
| InChI key | GGDUVPKRZGATLR-SPIKMXEPSA-N |
| packaging【包装】 | 5 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS05,GHS06 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H301 - H315 - H318 - H335 |
| Precautionary Statements | P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310 |
| Hazard Classifications【危险分类】 | Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
