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2-氯-2′-脱氧腺苷
2-Chloro-2′-deoxyadenosine
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3274189 | 10 MG | 3640 | |||
| 3274189 | 25 MG | 7350 |
产品别名
4291-63-8
2-氯-2′-脱氧腺苷
2-Chloro-2′-deoxyadenosine
Cladribine
CdA
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C10H12ClN5O3 |
| Molecular weight | 285.69 |
| MDL number | MFCD00153939 |
| PubChem Substance ID【PubChem化学物质编号】 | 24892693 |
| NACRES | NA.51 |
| Application【应用】 | 2-Chloro-2′-deoxyadenosine (2-CdA) is a chlorinated purine nucleoside with activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL) and multiple myeloma (MM). 2-CdA resists ADA degradation and is phosphorylated to CdATP in lymphocytes. CdATP incorporation into DNA induces strand breaks and the activation of apoptosis. 2-CdA may also be used in studies involving the inhibition of DNA polymerase(s). Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK). Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK). Clinically used for treatment of hairy cell leukemia, chronic lymphocytic leukemia and other indolent leukemias. |
| Biochem/physiol Actions【生化/生理作用】 | Deoxyadenosine analog resistant to adenosine deaminase; antileukemic with immunosuppressive activity |
产品性质
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder or crystals |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Nc1nc(Cl)nc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO)O3 |
| InChI | 1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1 |
| InChI key | PTOAARAWEBMLNO-KVQBGUIXSA-N |
| Gene Information | human ... NP(4860) rat ... Adora1(29290), Adora2a(25369), Adora3(25370) |
| packaging【包装】 | 10 mg in poly bottle 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS06,GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H301 - H341 - H361fd - H372 |
| Precautionary Statements | P201 - P202 - P260 - P264 - P270 - P301 + P310 |
| Hazard Classifications【危险分类】 | Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1 |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
