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聚合物键合型 2-氯代三苯甲基氯

2-Chlorotrityl chloride, polymer-bound
产品编号:3275906
规格:200-400 mesh, extent of labeling: 1.0-1.5 mmol/g Cl loading, 1 % cross-linked
CAS NO:42074-68-0
包装规格:1 G,5 G
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
32759061 G815
32759065 G2840
产品别名

42074-68-0

聚合物键合型 2-氯代三苯甲基氯

2-Chlorotrityl chloride, polymer-bound

2,α-Dichlorobenzhydryl-polystyrene crosslinked with divinylbenzene

结构式
基本信息
Beilstein
1983914
MDL number
MFCD00040399
PubChem Substance ID【PubChem化学物质编号】
24877876
Application【应用】
  • Acid labile resin used in Fmoc-based solid phase peptide synthesis.
  • Mild acidic cleavage conditions lead to the release of the peptide acid where fully protected peptides can be released if desired.
  • 2-Chlorotrityl chloride resins prevent racemization of the first amino acid and are thus very useful when racemic mixtures are forming (common with residues such as His or Cys).
  • This resin also prevents diketopiperazide formation, which can be an issue with proline C-terminal peptide sequences.

Use:
  • Attachment of the first amino acid residue is effected by stirring the resin, the protected amino acid, and excess diisopropylethylamine (DIEA) in dichloromethane.
  • Cleavage of the final protected peptide fragment is achieved under very mild conditions using either acetic acid/trifluoroethanol (TFE)/dichloromethane (1:1:8; v/v/v), hexafluoroisopropanol (HFIP)/dichloromethane (1:4; v/v) or simply 0.5% trifluoroacetic acid/dichloromethane (v/v).
  • Higher concentrations of TFA can be used if retention of peptide side chaing protecting groups is unimportant. Note that trityl chloride is moisture-sensitive, and, therefore, should be stored and handled appropriately.
  • If the resin becomes deactivated, treatment with acetyl chloride or SOCl2 in toluene before use is recommended to restore its activity.
产品性质
Quality Level【质量水平】
100
crosslinking【交联】
1 % cross-linked
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
extent of labeling【标记范围】
1.0-1.5 mmol/g Cl loading
Particle size【粒径】
200-400 mesh
application(s)
peptide synthesis
SMILES string
Clc1ccccc1C(Cl)(c2ccccc2)c3ccccc3
InChI
1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H
InChI key
JFLSOKIMYBSASW-UHFFFAOYSA-N
packaging【包装】
1, 5 g in glass bottle
安全信息
Pictograms【象形图】
GHS07
Signal word【警示用语:】
Warning
Hazard Statements
H315 - H319 - H335
Precautionary Statements
P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
Hazard Classifications【危险分类】
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs【靶器官】
Respiratory system
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
dust mask type N95 (US), Eyeshields, Gloves
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