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3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione hydrochloride
产品别名
294675-79-9
3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione hydrochloride
Erk Inhibitor
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H16N2O3S · HCl |
| Molecular weight | 328.81 |
| MDL number | MFCD09038681 |
| PubChem Substance ID【PubChem化学物质编号】 | 24891079 |
| NACRES | NA.77 |
| Application【应用】 | 3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione is an extracellular signal-regulated kinase (ERK) docking domain inhibitor. ERK inhibitors have been used to study traumatic brain injuries. |
| Biochem/physiol Actions【生化/生理作用】 | 3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione is extracellular signal-regulated kinase (ERK) docking domain inhibitor. Inhibits ERK binding rather then ERK activity at the ATP domain. IC50 = 25 μM in HeLa, A549, and SUM-159 tumor cells. Currently, no specific inhibitors of the ERK proteins exist. Preferentially binds to ERK2 with a Kd of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1, but exhibits little effect on ERK1/2 phosphorylation by MEK1/2. |
| Features and Benefits【特点和优势】 | This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated under inert gas |
| color【颜色】 | off-white |
| solubility【溶解性】 | DMSO: ≥4 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cl[H].CCOc1ccc(cc1)C=C2SC(=O)N(CCN)C2=O |
| InChI | 1S/C14H16N2O3S.ClH/c1-2-19-11-5-3-10(4-6-11)9-12-13(17)16(8-7-15)14(18)20-12;/h3-6,9H,2,7-8,15H2,1H3;1H/b12-9+; |
| InChI key | PQVLWVGMXJPJLG-NBYYMMLRSA-N |
| packaging【包装】 | 5 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
