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(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate
| 产品编号： | 3305719 |
| 规格： | ≥97% (HPLC), solid |
| CAS NO： | 182485-36-5 |
| 包装规格： | 10 MG，50 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
182485-36-5
(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate
TPMPA hydrate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C6H12NO2P · xH2O |
| Molecular weight | 161.14 (anhydrous basis) |
| PubChem Substance ID【PubChem化学物质编号】 | 24278172 |
| NACRES | NA.77 |
| Application【应用】 | (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate has also been used as γ-aminobutyric acid C (GABAc) blocker in retinal ganglion cells. TPMA has been used as a GABAC receptor antagonist to study the role of inner retinal inhibition in midget ganglion cells. TPMPA has also been used to study the role of GABAC receptor antagonists in suppressing orientation selectivity in ganglion cells. |
| Biochem/physiol Actions【生化/生理作用】 | TPMPA is a hybrid of isoguvacine and 3-APMPA designed to retain affinity for GABAC receptors but not to interact with GABAA or GABAB receptors. Electrical assays show that TPMPA is a competitive antagonist of cloned human mu 1 GABAC receptors expressed in Xenopus laevis oocytes (Kb approx. 2 μM). TPMPA is >100-fold weaker as an inhibitor of rat brain GABAA receptors expressed in oocytes (Kb approx. 320 μM) and has only weak agonist activity on GABAB receptors assayed in rat hippocampal slices (EC50 approx. 500 μM). TPMPA may be used to investigate GABAC receptor function in the outer retina and in any other areas of the nervous system in which these types of receptor are present. |
| Features and Benefits【特点和优势】 | This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. This compound is featured on the GABAC Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
| Preparation Note【制备说明】 | (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) hydrate is soluble in water at 16 mg/ml, but is insoluble in DMSO. |
| Legal Information【法律信息】 | Sold in the USA under exclusive license from the University of California. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | H2O: 16 mg/mL DMSO: insoluble |
| SMILES string | [H]O[H].CP([O-])(=O)C1=CC[NH2+]CC1 |
| InChI | 1S/C6H12NO2P.H2O/c1-10(8,9)6-2-4-7-5-3-6;/h2,7H,3-5H2,1H3,(H,8,9);1H2 |
| InChI key | GXVWAQPRAQORGS-UHFFFAOYSA-N |
| packaging【包装】 | 10, 50 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
