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4E1RCat
产品别名
4E1RCat
4-[(3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenylpyrrol-1-yl]benzoic acid
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C28H18N2O6 |
| Molecular weight | 478.45 |
| MDL number | MFCD01931282 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825222 |
| NACRES | NA.77 |
| Application【应用】 | 4E1RCat was used to inhibit new protein synthesis in transformed primary chicken embryo fibroblasts. |
| Biochem/physiol Actions【生化/生理作用】 | 4E1RCat ilnhibits the eIF4F translation initiation complex by binding to IF4E b and inhibiting the interaction between IF4E:eIF4G (IC50 = 3.2 μM). In in vitro translation experiments using MDA-MB-231 cells, 4E1RCat dose dependently inhibited cap-dependent translation, led to a decrease in polysome and 80S ribosomal subunits and reduced levels of the eIF4F-dependant proteins Mcl-1 and c-Myc. |
| Features and Benefits【特点和优势】 | This compound is featured on the MAPKAPs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | faint brown to dark brown-red |
| solubility【溶解性】 | DMSO: ≥5 mg/mL |
| originator【创始人】 | Merck & Co., Inc., Kenilworth, NJ, U.S. |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | OC(=O)c1ccc(cc1)N2C(=O)\C(=C\c3ccc(o3)-c4ccc(cc4)[N+]([O-])=O)C=C2c5ccccc5 |
| InChI | 1S/C28H18N2O6/c31-27-21(16-24-14-15-26(36-24)19-6-12-23(13-7-19)30(34)35)17-25(18-4-2-1-3-5-18)29(27)22-10-8-20(9-11-22)28(32)33/h1-17H,(H,32,33)/b21-16+ |
| InChI key | BBQRBOIMSKMFFO-LTGZKZEYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
