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5-氯-2′-脱氧尿苷

5-Chloro-2′-deoxyuridine
产品编号:3324331
规格:thymidine analog
CAS NO:50-90-8
包装规格:100 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3324331100 MG1220
产品别名

50-90-8

5-氯-2′-脱氧尿苷

5-Chloro-2′-deoxyuridine

CldU

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C9H11ClN2O5
Molecular weight
262.65
MDL number
MFCD00006531
PubChem Substance ID【PubChem化学物质编号】
24892910
NACRES
NA.51
Application【应用】
5-Chloro-2′-deoxyuridine has been used to:
  • study cell cycle dynamics by immunohistochemical analysis and double S-phase labeling using animal models
  • analyze cell cycle length using an animal model
  • label HEK293T cells for molecular combing assay

Biochem/physiol Actions【生化/生理作用】
DNA labeled with 5-chloro-2′-deoxyuridine (CldU) serves as an effective tool to analyze and quantify DNA replication, repair, and recombination. CldU is a potent mutagen, clastogen, and toxicant. It is used as a thymidine analog and is found to alter the dNTP pools and might lead to cell-cycle arrest. CldU produces sister-chromatid exchange but has less response to ionizing radiation compared to other thymine analogs. 5-Chloro-2′-deoxyuridine (CldU) is used to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors. When used with antibody based immunofluorescent imaging, 5-Chloro-2′-deoxyuridine incorporation may be used in protocols to identify sites of DNA replication. CldU may be used as a labeling substrate in conjunction with other halogenated uridine labeling substrates such as iododeoxyuridine (IdU).
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
solubility【溶解性】
1 M NH4OH: 20 mg/mL, clear, colorless to faintly yellow
storage temp.【储存温度】
−20℃
SMILES string
OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(Cl)C(=O)NC2=O
InChI
1S/C9H11ClN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChI key
NJCXGFKPQSFZIB-RRKCRQDMSA-N
packaging【包装】
100 mg in poly bottle
安全信息
Pictograms【象形图】
GHS07,GHS08
Signal word【警示用语:】
Warning
Hazard Statements
H302 + H312 + H332 - H351
Precautionary Statements
P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
Hazard Classifications【危险分类】
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
dust mask type N95 (US), Eyeshields, Gloves
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