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6, 2′, 4′-trimethoxyflavone
产品别名
720675-90-1
6, 2′, 4′-trimethoxyflavone
TMF
2-(2,4-Dimethoxyphenyl)-2,3-dihydro-6-methoxy-4H-1-benzopyran-4-one
Trimethoxyflavone
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H16O5 |
| Molecular weight | 312.32 |
| MDL number | MFCD03412381 |
| PubChem Substance ID【PubChem化学物质编号】 | 329826784 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | 6, 2′, 4′-trimethoxyflavone is a selective aryl hydrocarbon receptor (AHR) antagonist with no partial agonist activity. The role of the transcription factor aryl hydrocarbon receptor (AHR) in biology is still under evaluation and has expanded beyond that of a xenobiotic sensor and regulator of detoxification. Inhibition of AHR activity by antagonists could result in anti-inflammatory actions. 6, 2′, 4′-trimethoxyflavone (TMF) is a pure AHR antagonist. The compound compete with agonists, such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene (B[a]P), thus effectively inhibiting AHRmediated transactivation of a heterologous reporter and endogenous targets e.g. CYP1A1. TMF also exhibits no species or promoter dependency with regard to AHR antagonism. Thus it represents an improved tool allowing for more precise dissection of AHR function. The AHR along with immune functions, is also associated with endocrine processes and cancer development. |
| Preparation Note【制备说明】 | 6, 2′, 4′-trimethoxyflavone is soluble in DMSO at a concentration that is greater than 5 mg/ml. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated protect from light |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: >5 mg/mL |
| storage temp.【储存温度】 | room temp |
| SMILES string | COc1ccc(c(OC)c1)C2=CC(=O)c3cc(OC)ccc3O2 |
| InChI | 1S/C18H16O5/c1-20-11-5-7-16-14(8-11)15(19)10-18(23-16)13-6-4-12(21-2)9-17(13)22-3/h4-10H,1-3H3 |
| InChI key | WUWFDVDASNSUKP-UHFFFAOYSA-N |
| packaging【包装】 | 10, 50 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS06 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| Hazard Classifications【危险分类】 | Acute Tox. 3 Oral |
| Storage Class Code【储存分类代码】 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
