(S)-(-)-Bay K8644

C₁₆H₁₅F₃N₂O₄

356.30

MFCD00153769

24891582

NA.77

(S)-(-)-Bay K8644, a dihydropyridine compound is a Ca²⁺ channel activator. It is an enantiomer of Bay K 8644.

(S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices. It has also been used as a LTCC agonist to induce arrhythmia in rats.

(S)-(-)-Bay K8644 enhances Ca²⁺ current, whereas the (+)-Bay K 8644 is a weak Ca²⁺ channel antagonist. Bay K 8644 is lipophilic and it effectively scavenges superoxide anions.

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Manufactured and sold with the permission of Bayer AG.

100

≥98% (HPLC)

solid

yellow

H₂O: slightly soluble
ethanol: soluble (Organic solutions are stable for at least 20 days at RT.)

2-8℃

COC(=O)C1=C(C)NC(C)=C([C@H]1c2ccccc2C(F)(F)F)[N+]([O-])=O

1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1

ZFLWDHHVRRZMEI-ZDUSSCGKSA-N

human ... ADORA3(140)
rat ... Adora1(29290), Adora2a(25369)

1, 5 mg in glass bottle

GHS07

Warning

H315 - H319

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

Eye Irrit. 2 - Skin Irrit. 2

11 - Combustible Solids

WGK 3

dust mask type N95 (US), Eyeshields, Gloves