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ALX 5407 hydrochloride
产品别名
200006-08-2
ALX 5407 hydrochloride
N-[3-(4′-Fluorophenyl)-3-(4′-phenylphenoxy)propyl]sarcosine hydrochloride
NFPS hydrochloride
ALX-5407 hydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C24H24NO3F·HCl |
| Molecular weight | 429.91 |
| MDL number | MFCD09971056 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825613 |
| NACRES | NA.77 |
| Application【应用】 | ALX 5407 hydrochloride has been used as a glycine transporter (GlyT1) inhibitor to test its effect on inhibitory postsynaptic current and N-methyl- |
| Biochem/physiol Actions【生化/生理作用】 | ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC50 values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC50 > 100 mM). |
| Features and Benefits【特点和优势】 | This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 5 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cl.CN(CC[C@@H](Oc1ccc(cc1)-c2ccccc2)c3ccc(F)cc3)CC(O)=O |
| InChI | 1S/C24H24FNO3.ClH/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18;/h2-14,23H,15-17H2,1H3,(H,27,28);1H/t23-;/m1./s1 |
| InChI key | RPDGSZCYSJWQEE-GNAFDRTKSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07,GHS09 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 - H410 |
| Precautionary Statements | P273 - P301 + P312 + P330 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
