AM281

C₂₁H₁₉Cl₂IN₄O₂

557.21

MFCD01861180

24724384

NA.77

AM281 has been used as a cannabinoid 1 receptor antagonist:

• to study its effects on memory deficit following naloxone-precipitated morphine withdrawal in mice
• to study the role of CB1 receptor system in modulating acetaldehyde-induced effects in rats during the extinction-, relapse-, and conflict-experiments
• to study its effect on scopolamine-induced memory deficit using object recognition paradigm
• to block synthetic cannabinoid (HU210)-induced analgesia in the ventrolateral orbital cortex (VLO) to evaluate the effect of CB1 receptors on the VLO modulation of pain

AM281 is less lipophilic compared to its analog SR 141716A, a cannabinoid receptor antagonist. AM281 may prevent memory deficit post morphine withdrawal by inhibiting cannabinoid receptors in mice.
Potent and selective CB₁ cannabinoid receptor antagonist/inverse agonist

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

100

≥98% (HPLC)

powder

desiccated

white

DMSO: >6 mg/mL
H₂O: insoluble

2-8℃

Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(I)cc3)C(=O)NN4CCOCC4

1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)

AJFFBPZYXRNAIC-UHFFFAOYSA-N

rat ... Cnr1(25248)

10, 50 mg in glass bottle

GHS06

Danger

H300 - H315 - H319 - H335

P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338

Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Respiratory system

6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK 3

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges