Anti-ACE2 antibody produced in rabbit

NA.41

Angiotensin-converting enzyme-2 (ACE2) gene is mapped to human chromosome Xp22.2. The gene codes for a membrane-associated and secreted enzyme. Ace 2 is a human homolog of angiotensin-converting enzyme (ACE) and is found mainly on endothelium. In humans, Ace2 is exclusively expressed in heart, kidney, and testis. The protein is characterized with an N-terminal PD and a C-terminal collectrin-like domain (CLD).

Antibody was raised against a synthetic peptide corresponding to amino acids near the N terminus of human ACE2.

Angiotensin-converting enzyme-2 (ACE2) aids in maturation of angiotensin (Ang) by converting Ang I to Ang1-9. It may also play a role in the local renin-angiotensin system (RAS) in heart and kidney. Ace 2 serves as a functional receptor for severe acute respiratory syndrome–coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2), which is responsible for causing coronavirus disease 2019 (COVID-19). Reduced expression of Ace 2 might cause cardiovascular diseases.

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The action of this antibody can be blocked using blocking peptide SBP3500978.

Supplied at 1 mg/mL in PBS with 0.02% sodim azide.

rabbit

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

human

1 mg/mL

ELISA: suitable
immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: suitable

NP_068576

Q9BYF1

wet ice

−20℃

human ... ACE2(59272)

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