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Anti-Activin A antibody produced in goat
| 产品编号： | 3343122 |
| 规格： | affinity isolated antibody, lyophilized powder |
| 包装规格： | 0.1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Activin A antibody produced in goat
Activin A Antibody
基本信息
| MDL number | MFCD02095789 |
| NACRES | NA.41 |
| General description【一般描述】 | Activin A protein belongs to the transforming growth factor-β (TGF-β) superfamily. This protein is a homodimer of two βA subunits. The INHBA gene is located on the human chromosome at 7p14.1. |
| Immunogen【免疫原】 | recombinant human activin A expressed in CHO cells. |
| Application【应用】 | Anti-Activin A antibody can be used for immunohistochemistry (5-15 μg/mL), western blot (0.1 μg/mL) and neutralization assays. Anti-Activin A antibody produced in goat has been used in immunohistochemical staining. |
| Biochem/physiol Actions【生化/生理作用】 | Activin A protein is involved in regulating developmental genes such as cell cycle regulators like p21, p15, paired box protein (Pax-6) and hormones like follicle-stimulating hormone (FSH). This protein also regulates its antagonist like follistatin and mothers against decapentaplegic homolog 7 (SMAD7). Activin A protein binds to the type 1 receptor activin receptor type 1B (ActR1B) and type 2 receptor activin receptor 2A and 2B (ActRIIA and ActRIIB). Activin A gene is highly expressed in esophageal carcinoma, lung adenocarcinoma, and malignant pleural mesothelioma (MPM). This gene expression is decreased during breast cancer, neuroblastoma, and hepatocellular carcinoma (HCC). Activins bind to the type II Activin receptor triggering phosphorylation of type I Activin receptor (ALK4) and activation of downstream pathways such as proliferation and apoptosis. Activin acts as a tumor suppressor by reducing cell proliferation in cancer cells. |
| Physical form【外形】 | Lyophilized from 0.2 μm-filtered solution in phosphate buffered saline containing carbohydrates. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | goat |
| recombinant【重组】 | expressed in goat |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | lyophilized powder |
| species reactivity | human |
| technique(s) | ELISA: suitable immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL neutralization: suitable western blot: 0.1 μg/mL |
| UniProt accession no.【UniProt登记号】 | P08476 |
| application(s) | research pathology |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... INHBA(3624) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
