Anti-Activin Receptor IIA antibody produced in goat

MFCD01864595

NA.41

Activin is a disulfide-linked dimeric protein released by granulosa cells in the ovary and sertoli cells in the testis. It has several functions which include bone remodeling, neural cell differentiation, reproductive physiology, hematopoiesis and mesoderm induction. Activin will not bind directly to Type I activin receptors rather it will associate with the type II receptor-activin complex and start signal transduction. Activin Receptor IIA belongs to Ser/Thr protein kinase family, is highly conserved and can bind to inhibin, BMP-2, and BMP-7 with lower affinities. Goat anti-activin receptor IIA antibody reacts specifically with recombinant human activin receptor IIA. The antibody exhibits approximately 2% cross-reactivity with recombinant human activin receptor I and recombinant human activin receptor IIB.
The antibody has the ability to block receptor-ligand interaction. In ELISA assays, it will block 50% of the binding of recombinant human activin A to recombinant human activin receptor IIA/Fc chimera.

recombinant human activin receptor IIA expressed in Sf 21 insect cells.

Goat anti-Activin receptor IIB (ActRIIB) was used to detect activin receptor IIB in muscle fibroblasts by western blot. The antibody recognized activin receptor IIB at roughly 50kDa.
Anti-Activin Receptor IIA antibody can be used in in western blotting (working concentration:-0.1-0.2 μg/mL) and indirect ELISA (working concentration -0.5-1.0 μg/mL) for detecting human activin receptor IIA.
Goat Activin Receptor IIA antibody is suitable for immunohistochemistry assays at 15μg/ml.

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

200

goat

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

lyophilized powder

human

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 15 μg/mL
indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL

P27037

−20℃

human ... ACVR2A(92)

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WGK 3