Anti-Activin Receptor IIB antibody produced in goat

MFCD01864596

NA.41

Anti-Activin Receptor IIB recognizes recombinant human activin receptor IIB by methods such as immunoblotting and ELISA. The antibody can inhibit receptor-ligand interaction. In ELISA assays, the antibody can block 50% of the binding of recombinant human activin A to recombinant human activin receptor IIB/Fc chimera. Furthermore, the antibody exhibits 15% cross-reactivity with recombinant human activin receptor I. This antibody shows no cross reactivity with recombinant human activin receptor IA, IIA, and IB using ELISA and immunoblotting methods.
Activin is a disulfide-linked dimeric protein released by grandulosa cells in the ovary and sertoli cells in the testis. Activin Receptor IIB belongs to Ser/Thr protein kinase family and can transduce the activin signal from the cell surface to the cytoplasm. Activin will not bind directly to Type I activin receptors rather it will associate with the type II receptor-activin complex and start signal transduction. Many ligands signal through Activin Receptor IIB can regulate muscle growth. Anti-Activin Receptor IIB antibody can be used in flow cytometry and immunohistochemistry. Goat Anti- Activin Receptor IIB antibody reacts specifically with recombinant human activin receptor IIB. The product has shown no cross-reactivity for human activin receptor IA, recombinant human activin receptor IIA or recombinant human activin receptor IB.

purified, NSO-derived, recombinant human activin receptor IIB extracellular domain.

Goat anti-activin receptor IIB antibody can be used for immunohistochemistry (5 μg/mL) and flow cytometry (10 μL) applications.
Anti-Activin Receptor IIB can be used in western blotting (working concentration-0.1-0.2 μg/mL) for detecting human activin receptor IIB.

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose

200

goat

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

human

flow cytometry: 10 μL using 1-2.5 x 10⁵ cells (of a 25 μg/mL dilution)
immunohistochemistry: 5 μg/mL
western blot: 0.1-0.2 μg/mL

Q13705

−20℃

human ... ACVR2B(93)

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13 - Non Combustible Solids

WGK 2