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Anti-AIRE (AB2) antibody produced in rabbit
产品别名
Anti-AIRE (AB2) antibody produced in rabbit
Anti-APSI
Anti-AIRE1
Anti-Autoimmune regulator
Anti-APS1
Anti-PGA1
Anti-APECED
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | AIRE is a transcription factor that regulates the expression of autoantigens in T cells. Defects in AIRE have been linked to autoimmune polyendocrinopathy syndrome type 1 (APS1). Rabbit Anti-AIRE (AB1) antibody recognizes human, mouse, rat and bovine AIRE. |
| Immunogen【免疫原】 | Synthetic peptide directed towards the N terminal region of human AIRE |
| Application【应用】 | Rabbit Anti-AIRE (AB2) antibody can be used for western blot applications at a concentration of 0.5μg/ml. |
| Biochem/physiol Actions【生化/生理作用】 | The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). |
| Sequence【序列】 | Synthetic peptide located within the following region: HRTEIAVAVDSAFPLLHALADHDVVPEDKFQETLHLKEKEGCPQAFHALL |
| Physical form【外形】 | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | 58 kDa |
| species reactivity | dog, guinea pig, horse, rat, human, mouse |
| concentration【浓度】 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_000374 |
| UniProt accession no.【UniProt登记号】 | O43918 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... AIRE(326) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
