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Anti-ATG3 兔抗
Anti-ATG3 antibody produced in rabbit
| 产品编号： | 3346573 |
| 规格： | affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-ATG3 兔抗
Anti-ATG3 antibody produced in rabbit
Anti-Autophagy related 3 homolog (S. cerevisiae)
Anti-DKFZp564M1178
Anti-APG3L
Anti-MGC15201
Anti-PC3-96
Anti-APG3
Anti-FLJ22125
基本信息
| MDL number | MFCD09753844 |
| General description【一般描述】 | Autophagy-related protein 3 (ATG3) is a member of the autophagy-related protein family. It is a mammalian homolog of yeast Apg3p/ Atg3 is ubiquitously expressed in human tissues. ATG3 is a member of the autophagy-related protein family and is involved in the formation of the autophagosome. |
| Immunogen【免疫原】 | synthetic peptide corresponding to amino acids 17-32 of human Atg3, conjugated to KLH via a C-terminal cysteine residue. The corresponding sequence is identical in rat and mouse. |
| Application【应用】 | Anti-ATG3 antibody produced in rabbit has been used in western blotting and immunoprecipitation. |
| Biochem/physiol Actions【生化/生理作用】 | Autophagy-related protein 3 (ATG3) is involved in the formation of the autophagosome. the mammalian homolog of yeast Apg3p/Aut1p, is an E2-like enzyme that catalyzes the conjugation reaction between Atg8 and phosphatidylethanolamine (PE). Golgi-associated ATPase enhancer of 16 kDa (GATE-16), GABAA receptor-associated protein (GABARAP), and microtubule-associated protein light chain 3 (MAP-LC3) are substrates for Atg3. MAP-LC3 is the preferred substrate. Atg3 interacts with Atg7 to form an E1-E2 complex, and with Atg12, which is a substrate for Atg7 but not for Atg3. Moreover, overexpression of Atg3 facilitates the formation of the Atg12-Atg5 conjugate. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~36 kDa |
| species reactivity | rat, human, mouse |
| technique(s) | immunoprecipitation (IP): 5-10 μL using rat NRK cell lysate western blot: 2-4 μg/mL using whole extracts of human HeLa and mouse 3T3 cells |
| UniProt accession no.【UniProt登记号】 | Q9NT62 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... ATG3(64422) mouse ... Atg3(67841) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
