您的位置：首页 > 产品中心 > Anti-BRCA1 antibody produced in rabbit
Anti-BRCA1 antibody produced in rabbit
产品别名
Anti-BRCA1 antibody produced in rabbit
familial breast/ovarian cancer gene 1
BRCA1
Breast cancer type 1 susceptibility protein
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene involved in familial breast cancer, mapped to human chromosome 17q21. BRCA1 codes for an 1863-amino acid protein, and is expressed in several human tissues, including breast and ovary. The encoded protein is characterized with an N- terminal C3HC4 zinc finger domain, two nuclear localization sequences (NLS) required for translocation into the nucleus, and a C-terminal end rich in amino acid residues. |
| Immunogen【免疫原】 | The antiserum was produced against synthesized peptide derived from human BRCA1. Immunogen Range: 1391-1440 |
| Application【应用】 | Anti-BRCA1, C-Terminal antibody produced in rabbit has been used in proximity ligation assay. |
| Biochem/physiol Actions【生化/生理作用】 | Breast cancer susceptibility gene 1 (BRCA1) plays a vital role in DNA repair, chromatin remodeling, gene transcription and cell cycle regulation. Detection of BRCA1 gene allows early diagnosis of breast and ovarian cancer susceptibility in some individuals and also facilitates studies related to breast cancer biology. BRCA1 interacts with c-Myc, a proto-oncogene, to maintain genomic stability. Experimental studies reveals that germline mutations in BRCA1 gene causes breast and ovarian cancer. Increased expression of BRCA1 leads to growth retardation and tumor suppression in breast and ovarian cancer cells. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 207 kDa |
| species reactivity | human, rat |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | ELISA: 1:4000 immunohistochemistry: 1:50-1:100 |
| NCBI accession no.【NCBI登记号】 | P38398 |
| UniProt accession no.【UniProt登记号】 | P38398 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... BRCA1(672) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
