Anti-BRWD1 antibody produced in rabbit

HPA030945    Human Protein Atlas characterization data

BRWD1 (bromodomain and WD repeat domain containing 1) is also known as WDR9 (WD repeat 9). It encodes a putative protein of 2269 amino acids.WDR9 is present in the nucleus. BRWD1 belongs to a novel protein family which contains both WD40 repeat domains (seven) and dual bromodomains. It has 41 exons and 40 introns and spans around 125 kb of genomic sequence. BRWD1 is located on human chromosome 21q22.2.

bromodomain and WD repeat domain containing 1 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

BRWD1 (bromodomain and WD repeat domain containing 1) participates in chromatin remodeling. It helps in normal spermiogenesis and the oocyte–embryo transition. BRWD1 serves as a transcriptional regulator or co-regulator. It may play an important role in sex-specific nuclear remodeling events in oocytes and spermatids.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST78846.

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

Prestige Antibodies^® Powered by Atlas Antibodies

buffered aqueous glycerol solution

human

immunohistochemistry: 1:50-1:200

RTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKARAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVA

Q9NSI6

wet ice

−20℃

human ... BRWD1(54014)

12 - Non Combustible Liquids

WGK 1