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Anti-CAMK2δ-like (C-term) antibody produced in rabbit
| 产品编号： | 3350717 |
| 规格： | IgG fraction of antiserum, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-CAMK2δ-like (C-term) antibody produced in rabbit
CaM kinase II γ subunit
Anti-CaM-kinase II γ chain
Anti-Calcium/calmodulin-dependent protein kinase type II γ chain
CaMK-II γ subunit
Anti-CAMK2G
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Ca2+/calmodulin-dependent kinase II γ (CaMKIIγ) gene is mapped to human chromosome 10q22.2. The encoded protein is a multifunctional serine/threonine kinase and is specific to various substrates. CaMKII contains four isoforms: CaMKIIα/β/γ/δ. CaMKII is ubiquitously expressed in humans. The protein consists of an N-terminal catalytic domain, a regulatory domain, and a C-terminal association domain. CaM-kinase II (CAMK2) is a prominent Ser/Thr protein kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Likely autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state. CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. |
| Immunogen【免疫原】 | CAMK2 (NP_751911, 314-348) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-term region of human CAMK2 delta-like. |
| Biochem/physiol Actions【生化/生理作用】 | CaMKIIγ (Ca2+/calmodulin-dependent kinase II γ) is mostly expressed in tumor-initiating cells. CaMKIIγ regulates the progression of cancer cells in leukemia, lung cancer, and liver cancer. CaMKIIγ participates in the β-catenin, Stat3 (signal transducer and activator of transcription 3), and NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) signal pathways.. |
| Physical form【外形】 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human, rat, mouse |
| technique(s) | immunohistochemistry: 1:50-1:100 indirect ELISA: 1:1000 western blot: 1:100-1:500 |
| NCBI accession no.【NCBI登记号】 | NP_751911 |
| UniProt accession no.【UniProt登记号】 | O15378 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CAMK2(818) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
