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Anti-COG1 (C-TERMINAL) antibody produced in rabbit

产品编号:3354444
规格:~1.0 mg/mL, affinity isolated antibody
包装规格:200 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3354444200 μL5040
产品别名

Anti-COG1 (C-TERMINAL) antibody produced in rabbit

Anti-CDG2G

Anti-conserved oligomeric Golgi complex subunit 1

Anti-COG complex subunit 1

Anti-component of oligomeric golgi complex 1

Anti-low density lipoprotein receptor defect

Anti-LDLB

基本信息
NACRES
NA.41
General description【一般描述】
COG1 is a member of the conserved oligomeric Golgi (COG) complex. COG complex is an evolutionarily conserved multi-subunit protein complex. COG complex consists of eight distinct subunits organized in two heterotrimeric groups, Cog2-Cog3-Cog4 and Cog5-Cog6-Cog7, which are linked by the dimeric group formed by Cog1 and Cog8.
Conserved oligomeric Golgi (COG) subunit 1 is an essential component of the conserved oligomeric Golgi complex. It is encoded by the gene mapped to human chromosome 17q25.1.
Immunogen【免疫原】
peptide corresponding to the C-terminal region of human COG1, conjugated to KLH. The corresponding sequence is identical in mouse, rat and monkey COG1.
Application【应用】
Anti-COG1 (C-TERMINAL) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions【生化/生理作用】
COG1 is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates. It plays a role in the organization of the Golgi-localized complex. Mutations in COG1 in humans cause novel types of congenital disorders of glycosylation (CDG). COG complex regulates membrane trafficking and maintenance of Golgi glycosylation machinery in eukaryotic cells.
Conserved oligomeric Golgi (COG) complex plays a vital role in retrograde vesicular trafficking and glycosylation.
Physical form【外形】
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
产品性质
biological source【生物来源】
rabbit
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen ~110 kDa
species reactivity
human, mouse, rat
concentration【浓度】
~1.0 mg/mL
technique(s)
indirect immunofluorescence: 1-2 μg/mL using human HeLa cells.
western blot: 2.5-5.0 μg/mL using whole extracts of mouse LA-4 cells.
UniProt accession no.【UniProt登记号】
Q8WTW3
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... COG1(9382)
mouse ... Cog1(16834)
rat ... Cog1(303652)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
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