您的位置：首页 > 产品中心 > Anti-CTDSP1-V250 (C-term) antibody produced in rabbit
Anti-CTDSP1-V250 (C-term) antibody produced in rabbit
| 产品编号： | 3355699 |
| 规格： | saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-CTDSP1-V250 (C-term) antibody produced in rabbit
Anti-Nuclear LIM interactor-interacting factor 3
Anti-NLI-IF
Anti-NLI-interacting factor 3
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | saturated ammonium sulfate (SAS) precipitated |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | immunohistochemistry: 1:50-1:100 indirect ELISA: 1:1000 western blot: 1:100-1:500 |
| NCBI accession no.【NCBI登记号】 | NP_067021 |
| UniProt accession no.【UniProt登记号】 | Q9GZU7 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CTDSP1(58190) |
基本信息
| General description【一般描述】 | CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibited activated transcription from several promoter-reporter gene constructs, but expression of a mutant lacking phosphatase activity enhanced transcription. Neuronal gene transcription is repressed in nonneuronal cells by the repressor element-1 (RE1)-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF; 600571) complex. REST/NRSF recruits SCPs to neuronal genes that contain RE1 elements, leading to neuronal gene silencing in nonneuronal cells. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Likewise, small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells. Thus, SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes. |
| Immunogen【免疫原】 | CTDSP1 (NP_067021, 240-271) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human CTDSP1-V250 protein. |
| Physical form【外形】 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
