1,1-二甲基-4-苯基哌嗪碘化物

C₁₂H₁₉IN₂

318.20

3746109

200-213-0

MFCD00011976

24277832

NA.77

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) has been used as a non-selective nicotinic acetylcholine receptor (nAchR) agonist:

• to study the roles of α7 and α4β2 nAchRs in autonomic regulation of cardiovascular responses in urethane-anesthetized mice
• to study the mechanism involved in improving glucose tolerance in diet-induced obese (DIO) mice treated with DMPP
• to study its pharmacological effect on enteric viscerofugal neurons in the myenteric plexus of guinea-pig colon

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) is a non-selective nicotinic acetylcholine receptor (nAchR) agonist. It acts as a stimulating agent for sympathetic ganglia. DMPP exhibits specific action on ganglia and adrenal medullary tissue hence, it finds its application in the diagnosis of pheochromocytoma.

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

200

≥98% (TLC or titration)

234-238 ℃ (lit.)

H₂O: 21 mg/mL

−20℃

[I-].C[N+]1(C)CCN(CC1)c2ccccc2

1S/C12H19N2.HI/c1-14(2)10-8-13(9-11-14)12-6-4-3-5-7-12;/h3-7H,8-11H2,1-2H3;1H/q+1;/p-1

XFZJGFIKQCCLGK-UHFFFAOYSA-M

human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)
rat ... Chrna2(170945), Chrna3(25101), Chrna4(25590), Chrnb2(54239), Chrnb4(25103)

1, 10 g in glass bottle

11 - Combustible Solids

WGK 3

dust mask type N95 (US), Eyeshields, Gloves